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Related Experiment Videos

Renal vasculitis associated with ciprofloxacin

D J Shih1, S M Korbet, J J Rydel

  • 1Department of Medicine, Rush Presbyterian St Lukes Medical Center, Chicago, IL 60612, USA.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|September 1, 1995
PubMed
Summary

Ciprofloxacin treatment can cause acute kidney injury, including necrotizing vasculitis and interstitial nephritis. Discontinuing the antibiotic and using immunosuppressive therapy improved renal function in two patients.

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Area of Science:

  • Nephrology
  • Pharmacology
  • Pathology

Background:

  • Antibiotic-induced kidney injury is a significant clinical concern.
  • Ciprofloxacin is a commonly prescribed fluoroquinolone antibiotic.
  • Acute renal failure necessitates prompt diagnosis and management.

Observation:

  • Two patients developed acute renal failure during ciprofloxacin therapy.
  • Renal biopsies revealed necrotizing vasculitis and acute interstitial nephritis.

Findings:

  • Discontinuation of ciprofloxacin led to improved renal function.
  • Immunosuppressive therapy was initiated alongside antibiotic withdrawal.
  • The combination therapy resulted in recovery of kidney function.

Implications:

Related Experiment Videos

  • Ciprofloxacin should be considered in the differential diagnosis of acute kidney injury.
  • Early recognition and management of antibiotic-associated glomerulonephritis are crucial.
  • This case highlights the potential for fluoroquinolones to induce severe renal pathology.