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Taxol inhibits growth of mesothelioma xenografts
J M Lee1, H W Bruckner, L Szrajer
1Derald H. Ruttenberg Cancer Center, Mount Sinai Medical Center, New York, NY 10029, USA.
Background:
In vitro tests measuring inhibition of adenosine triphosphate activity predicted three mesothelioma xenografts would be sensitive to taxol.
Purpose:
The in vivo therapeutic efficacy of taxol was tested in nude mice carrying the subcutaneous tumors.
Methods:
Once tumor growth reached 100mm3 in size, intraperitoneal taxol, 30 mg/kg, on a day 1, 4, and 8 schedule, was administered to mice bearing subcutaneous mesothelioma xenografts.
Results:
Taxol inhibits the growth of all three cell lines. It produces actual tumor regression including some complete responses.
Conclusions:
Taxol is an active drug against mesothelioma. The in vitro cell lines and the in vivo system are useful tools for screening and developing new treatments for mesothelioma.
Insights
Taxol effectively inhibits mesothelioma tumor growth in vivo, demonstrating significant tumor regression. This study highlights taxol as a promising therapeutic agent for mesothelioma treatment.
Area of Science:
- Oncology
- Pharmacology
Background:
- In vitro assays measuring adenosine triphosphate inhibition predicted taxol sensitivity in three mesothelioma xenografts.
- Adenosine triphosphate inhibition serves as a predictive biomarker for taxol efficacy.
Purpose of the Study:
- To evaluate the in vivo therapeutic efficacy of taxol against subcutaneous mesothelioma xenografts in nude mice.
- To validate in vitro predictions of taxol's anti-mesothelioma activity.
Main Methods:
- Nude mice bearing subcutaneous mesothelioma xenografts were utilized for in vivo testing.
- Taxol was administered intraperitoneally at 30 mg/kg on days 1, 4, and 8, following tumor growth to 100 mm³.
- Standardized dosing and scheduling were employed to assess treatment response.
Main Results:
- Taxol demonstrated significant inhibition of growth across all three tested mesothelioma cell lines.
- Observed outcomes included actual tumor regression, with some instances of complete response.
- The drug exhibited potent anti-tumor activity in the established xenograft model.
Conclusions:
- Taxol is confirmed as an active and effective drug against mesothelioma.
- Both in vitro cell line screening and in vivo xenograft models are valuable for developing novel mesothelioma treatments.
- This research supports the continued investigation of taxol and similar agents for mesothelioma therapy.