[Should a signal-averaged electrocardiogram be requested in the evaluation of malaise and syncope?]

In order to determine whether signal-averaged electrocardiography was useful in the diagnosis of syncopal ventricular tachycardia, 244 subjects with malaise or unexplained syncope without documented ventricular tachycardia underwent endocavitary electrophysiological study and signal-averaged electrocardiography with a 25 Hz bandpass filter. Ninety-three patients had no apparent cardiac disease whereas 151 patients had cardiac problems. ventricular tachycardia was induced in 91 patients. Fifty-two of them (57%) had ventricular late potentials. Twenty-two patients without inducible ventricular tachycardia also had late potentials (14%). The diagnostic value of signal-averaged electrocardiography depended on the cardiac disease: in the absence of cardiac disease, its sensitivity was poor (31%) but the specificity was excellent (96%). In the presence of cardiac disease, the sensitivity improved (63%) but the specificity was not as good (67%). The lack of sensitivity in the group with cardiac disease generally concerned subjects with inducible rapid ventricular tachycardia. The authors conclude that signal-averaged electrocardiography should not be requested in the investigation of unexplained syncope in subjects without cardiac disease to demonstrate abnormal ventricular excitability which is very rate in these subjects. On the other hand it is more valuable in those with underlying cardiac disease although inducible rapid ventricular tachycardia may still escape detection.