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Related Experiment Videos

False 'hematuria' due to bacteriuria

M H Lam1

  • 1Department of Microbiology, Royal Melbourne Hospital, Parkville, Victoria, Australia.

Archives of Pathology & Laboratory Medicine
|August 1, 1995
PubMed
Summary

Bacteriuria, the presence of bacteria in urine, can cause false-positive results on dipstick urinalysis for microhematuria. This finding is crucial for accurate urinary tract infection diagnosis.

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Area of Science:

  • Clinical chemistry
  • Microbiology
  • Urology

Background:

  • Dipstick urinalysis is a common screening tool for urinary tract diseases.
  • Microhematuria, the presence of red blood cells in urine, can indicate various renal and urinary tract pathologies.
  • Bacteriuria is often associated with urinary tract infections.

Purpose of the Study:

  • To investigate the impact of bacteriuria on the accuracy of dipstick urinalysis for detecting microhematuria.
  • To determine if bacteria in urine can lead to false-positive results for blood detection.

Main Methods:

  • Urine samples from 246 patients with suspected urinary tract diseases were analyzed.
  • Samples with positive dipstick readings for blood underwent microscopic examination and bacterial culture.
  • Patients were categorized based on the presence or absence of bacteriuria and hematuria.

Main Results:

  • Among patients with normal erythrocyte counts, 7% had polymicrobic cultures.
  • Bacteriuric patients with slight hematuria showed significantly higher dipstick blood readings compared to abacteriuric patients.
  • Hydroperoxidase, an enzyme produced by bacteria, was detected in a high percentage of bacterial isolates.

Conclusions:

  • Bacteriuria can lead to false-positive dipstick urinalysis results for microhematuria.
  • This phenomenon may complicate the interpretation of urinalysis in patients with urinary tract diseases.
  • Further investigation may be needed to differentiate true microhematuria from bacteriuria-induced false positives.

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