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A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned
M T Webster1, N Groome, P T Francis
1Miriam Marks Department of Neurochemistry, Institute of Neurology, London, U.K.
The Biochemical Journal
|August 15, 1995
Abstract:
A monoclonal antibody, 3B11, was raised to a novel protein, amyloid precursor-like protein 2, which did not recognize amyloid precursor protein. Multiple bands were detected in human brain fractions and cell lysate by Western blotting, indicating the presence of isoforms, 3B11 immunoreactivity was also detected in cerebrospinal fluid and conditioned medium, indicating that the protein is secreted. Immunocytochemistry revealed 3B11 immunoreactivity in sections of human brain.