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Cyclin D1 as a cellular proto-oncogene

S Bates1, G Peters

  • 1Imperial Cancer Research Fund Laboratories, London, UK.

Seminars in Cancer Biology
|April 1, 1995
PubMed
Summary
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Cyclin D1 overexpression, often due to chromosomal changes, is linked to human cancers and acts as a cellular proto-oncogene. Its oncogenic role involves interactions with cell cycle regulators like cyclin-dependent kinases and tumor suppressor genes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Deregulated cyclin D1 expression is observed in numerous human cancers.
  • Overexpression frequently stems from specific chromosomal abnormalities, suggesting a significant role in tumorigenesis.
  • Cyclin D1 is implicated in virally induced murine tumors and transgenic models.

Purpose of the Study:

  • To establish cyclin D1 as a cellular proto-oncogene.
  • To elucidate the oncogenic properties of cyclin D1.
  • To understand the functional interactions of cyclin D1 in cancer development.

Main Methods:

  • Analysis of cyclin D1 expression in human cancers.
  • Investigation of cyclin D1 in viral and transgenic mouse models.
  • Examination of cyclin D1 effects in transfected rodent cells.

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Main Results:

  • Cyclin D1 exhibits characteristics of a cellular proto-oncogene based on its expression patterns and effects in experimental models.
  • Ectopic expression of cyclin D1 in transgenic models mimics features of naturally occurring tumors.
  • Functional interactions with cyclin-dependent kinases, retinoblastoma gene product, and MTS1/p16 were identified.

Conclusions:

  • Cyclin D1 possesses oncogenic properties and functions as a cellular proto-oncogene.
  • Its deregulation is a key factor in the pathogenesis of various human cancers.
  • Understanding cyclin D1's interactions with cell cycle regulators is crucial for cancer research.