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Related Experiment Videos

Parenteral iron dextran therapy: a review

D L Burns1, E A Mascioli, B R Bistrian

  • 1Department of Medicine, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.

Nutrition (Burbank, Los Angeles County, Calif.)
|March 1, 1995
PubMed
Summary

Iron dextran offers a parenteral treatment for iron deficiency anemia when oral therapies fail. While effective, this iron supplement can cause side effects, necessitating a test dose and caution during infection.

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Area of Science:

  • Hematology
  • Pharmacology

Background:

  • Iron deficiency anemia is a prevalent global nutritional disorder.
  • Oral iron therapy is often poorly tolerated, necessitating alternative treatments.
  • Parenteral iron dextran has been used for over 30 years to treat anemia.

Purpose of the Study:

  • To review the efficacy and safety of iron dextran for parenteral iron therapy.
  • To highlight administration routes, potential side effects, and contraindications.

Main Methods:

  • Review of existing literature on iron dextran therapy.
  • Analysis of administration routes (intramuscular, intravenous).
  • Assessment of safety profile, including anaphylaxis risk and test dose recommendations.

Main Results:

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  • Iron dextran is an effective treatment for iron deficiency anemia refractory to oral iron.
  • Both intramuscular and intravenous administration carry risks of side effects.
  • A test dose is crucial for assessing anaphylaxis risk prior to full therapeutic administration.

Conclusions:

  • Parenteral iron dextran is a proven effective and safe treatment for iron deficiency anemia.
  • Careful administration and monitoring are essential due to potential side effects.
  • Iron dextran supplementation should be avoided in patients with active infections.