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A non-ionic water-soluble pentaphyrin derivative. Synthesis and cytotoxicity
1Department of Chemistry and Biochemistry, University of Texas at Austin 78712, USA.
Bioorganic & Medicinal Chemistry
|May 1, 1995
Abstract:
The synthesis of the water soluble tetrahydroxypentaphyrin derivative, 1, is described. This species, which forms complexes with both small neutral molecules and uranyl cation, has been studied as a possible cytotoxic agent. Cytotoxic studies performed with the human T lymphoma cell line (JURKAT) revealed that pentaphyrin 1 exhibits toxicity at microM concentrations comparable with other water soluble, porphyrin-type systems such as the pyridinium metalloporphyrins.