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Related Experiment Videos

Spinning tails

D J DeRosier1

  • 1Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02254, USA.

Current Opinion in Structural Biology
|April 1, 1995
PubMed
Summary
This summary is machine-generated.

The bacterial flagellar motor

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Area of Science:

  • Microbiology
  • Structural Biology
  • Biochemistry

Background:

  • The bacterial flagellar motor is a complex nanomachine responsible for bacterial motility.
  • Key components include torque-generating switch proteins located in the cytoplasm, extending from the basal body.

Purpose of the Study:

  • To elucidate the structure and function of the protein-subunit export channel in the bacterial flagellar filament.
  • To gain insights into the intricate machinery governing protein export and assembly.

Main Methods:

  • Utilized cryo-electron microscopy (cryo-EM) to generate 10 Å resolution maps of the bacterial filament.
  • Focused on analyzing the structural details of the protein-subunit export channel.

Main Results:

  • Identified an unusual alpha domain within the bacterial filament structure.
  • This alpha domain functions as the protein-subunit export channel, crucial for flagellar assembly.

Conclusions:

  • The study provides high-resolution structural insights into the bacterial flagellar protein export machinery.
  • Understanding these mechanisms is vital for comprehending flagellar assembly and function.