Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Solid malignant neoplasms after childhood irradiation: decrease of the relative risk with time after irradiation

F de Vathaire1, A Shamsaldin, E Grimaud

  • 1INSERM, U. 351, Département de biostatistique et d'épidémiologie, Institut Gustave-Roussy, Villejuif, France.

Comptes Rendus De L'Academie Des Sciences. Serie III, Sciences De La Vie
|April 1, 1995
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Testing quantum electrodynamics in extreme fields using helium-like uranium.

Nature·2024
Same author

Cancer therapy-related cardiac dysfunction after radiation therapy for breast cancer: results from the BACCARAT cohort study.

Cardio-oncology (London, England)·2024
Same author

Mothership versus Drip-and-Ship for stroke in a rural area: A French prospective observational study.

Revue neurologique·2024
Same author

A scoping review on tools and methods for trait prioritization in crop breeding programmes.

Nature plants·2024
Same author

Testing quantum electrodynamics in extreme fields using helium-like uranium.

Nature·2024
Same author

Fungal Planet description sheets: 1436-1477.

Persoonia·2024

Childhood cancer survivors receiving radiotherapy face a higher risk of developing a second solid malignant neoplasm (SMN). This risk is elevated for younger patients and peaks 15-20 years post-irradiation.

Area of Science:

  • Oncology
  • Radiation Oncology
  • Epidemiology

Background:

  • The long-term risks of solid cancer incidence following childhood radiotherapy are not fully understood.
  • Assessing these risks is crucial for improving radioprotection strategies in pediatric cancer patients.

Purpose of the Study:

  • To investigate the temporal patterns of solid second malignant neoplasm (SMN) occurrence after childhood radiotherapy.
  • To evaluate the influence of age at irradiation and time since treatment on SMN risk.

Main Methods:

  • A cohort study of 1,055 children treated with radiotherapy for a first childhood cancer across 8 European centers (1942-1985).
  • Mean follow-up of 19 years, comparing observed SMN incidence to expected rates from the general population.
  • Analysis of risk factors including age at irradiation, time since irradiation, and radiation dose.

Related Experiment Videos

Main Results:

  • 26 solid SMNs were observed, compared to 5.6 expected, indicating a significantly increased risk.
  • Higher excess relative risk and excess absolute risk of SMN were found in younger children at the time of irradiation.
  • The excess relative risk of SMN peaked 15-20 years post-irradiation and subsequently decreased over time, even after adjusting for covariates.

Conclusions:

  • Childhood cancer survivors treated with radiotherapy have an elevated risk of developing solid second malignant neoplasms.
  • Younger age at irradiation and the time elapsed since treatment are significant factors influencing SMN development.
  • Findings underscore the importance of long-term surveillance and refined radioprotection measures for pediatric cancer survivors.