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Clusterin: physiologic and pathophysiologic considerations

M E Rosenberg1, J Silkensen

  • 1Department of Medicine, University of Minnesota, Minneapolis 55455, USA.

The International Journal of Biochemistry & Cell Biology
|July 1, 1995
PubMed
Summary
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Clusterin, a protein found in bodily fluids, has diverse roles in normal physiology and is notably induced during various diseases. Its specific functions and disease-related roles require further investigation.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pathophysiology

Background:

  • Clusterin is a ubiquitous heterodimeric glycoprotein present in most biological fluids.
  • Proposed physiological functions include complement regulation, lipid transport, and apoptosis initiation.
  • Clusterin expression is significantly induced in numerous disease states.

Purpose of the Study:

  • To review the known physiological functions of clusterin.
  • To explore the pathophysiological roles of clusterin in disease.
  • To speculate on the function of clusterin in disease pathogenesis.

Main Methods:

  • Literature review of physiological and pathophysiological studies on clusterin.
  • Analysis of clusterin's distribution and in vitro properties.

Related Experiment Videos

  • Synthesis of current knowledge on clusterin's role in disease.

    • Main Results:

    • Clusterin exhibits diverse functions such as complement regulation and membrane protection.
    • Its expression is upregulated in conditions like Alzheimer's disease, atherosclerosis, and kidney diseases.
    • The precise molecular triggers and functional significance of induced clusterin in disease remain unclear.

    Conclusions:

    • Clusterin plays multifaceted roles in both normal physiology and disease.
    • Understanding the induction and function of clusterin in disease is crucial.
    • Further research is needed to elucidate clusterin's specific roles in various pathological conditions.