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Retinal dopamine and lens-induced refractive errors in chicks

S S Guo1, J G Sivak, M G Callender

  • 1School of Optometry, Department of Biology, University of Waterloo, Ontario, Canada.

Current Eye Research
|May 1, 1995
PubMed
Summary

Retinal dopamine levels change with induced refractive errors in chicks. Dopamine and DOPAC decreased in myopia and increased in hyperopia, suggesting a role in refractive development.

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Biochemistry

Background:

  • Refractive errors, such as myopia and hyperopia, are a significant global health concern.
  • The precise mechanisms underlying refractive error development, particularly lens-induced changes, require further elucidation.
  • The role of neurotransmitters in ocular development and refractive error progression is an area of active research.

Purpose of the Study:

  • To investigate the relationship between retinal dopamine levels and lens-induced refractive errors in a chick model.
  • To determine if changes in dopamine and its metabolite 3,4-dihydroxy-phenylacetic acid (DOPAC) correlate with induced myopia or hyperopia.

Main Methods:

  • Chickens were subjected to two weeks of wear with either +10D or -10D lenses to induce hyperopia or myopia, respectively.

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  • High-performance liquid chromatography with ultraviolet detection (HPLC-UV) was employed to quantify retinal dopamine and DOPAC levels.
  • Retinal dopamine and DOPAC concentrations were compared between eyes with induced refractive errors and control eyes.

    • Main Results:

    • Chick eyes treated with +10D lenses developed hyperopia (+8.29 +/- 0.43D).
    • Chick eyes treated with -10D lenses developed myopia (-11.69 +/- 0.74D).
    • Myopic eyes showed reduced levels of retinal dopamine and DOPAC compared to controls.
    • Hyperopic eyes exhibited increased levels of retinal dopamine and DOPAC compared to controls.

    Conclusions:

    • Retinal dopamine and its metabolite DOPAC levels are altered in response to lens-induced refractive errors in chicks.
    • These findings suggest that retinal dopamine plays a role in the development of lens-induced refractive errors.
    • Further research into the dopaminergic system's involvement in refractive error development is warranted.