[Idiopathic acute renal failure in nephrotic syndrome--a report of 10 cases]

Ten cases of idiopathic acute renal failure (IARF) in idiopathic nephrotic syndrome (NS) were reported. Heavy proteinuria and severe edema were the main clinical manifestations in these cases. Sudden oliguria, decrease of urinary osmolarity and increase of blood urea nitrogen and creatinine occurred without any difinite cause. Pathological examination showed normal or near normal glomeruli, diffuse interstitial edema and patchy necrosis of the tubular cells. The renal function in all the patients recovered after therapy with diuretics, prednisone, etc. It is shown that IARF in idiopathic NS commonly occurred in patients with normal or near normal glomeruli, for example, minimal change disease (6/10 cases), mild mesangial proliferative glomerulonephritis (4/10 cass). The incidence of IARF in idiopathic NS was 4.1% (10/245 cases), the IARF was mostly reversible.