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[Epidemiological investigation of Campylobacter Jejuni infection in children]
1Department of Epidemiology School of Public Health West China University of Medical Sciences, Chengdu.
Insights
Campylobacter jejuni infections are common in children with diarrhea, particularly toddlers. This bacteria can be found year-round, with higher rates in warmer months, and also affects healthy children in group settings.
Area of Science:
- Pediatric Infectious Diseases
- Microbiology
- Epidemiology
Background:
- Campylobacter jejuni is a significant cause of bacterial gastroenteritis in children worldwide.
- Understanding the epidemiology and transmission dynamics of C. jejuni in pediatric populations is crucial for public health interventions.
Purpose of the Study:
- To investigate the prevalence and seasonality of Campylobacter jejuni infection in children with diarrhea in Chengdu.
- To assess the occurrence of C. jejuni in healthy children and explore potential risk factors.
- To analyze the drug resistance patterns and genetic relatedness of C. jejuni strains in pediatric infections.
Main Methods:
- Conducted an epidemiological survey of 1,092 children with diarrhea and a sample of healthy children in Chengdu from 1987 to 1989.
- Utilized bacterial isolation and identification techniques to detect C. jejuni.
- Performed drug resistance spectrum analysis and plasmid analysis on isolated strains.
Main Results:
- The detection rate of Campylobacter in children with diarrhea was 11.36%, with the highest incidence in the 1-2 year age group.
- C. jejuni was detected year-round in children with acute diarrhea, with peak rates in spring and summer.
- Campylobacter was found in 5.09% of healthy children, with variations observed between different kindergarten settings.
Conclusions:
- Campylobacter jejuni infection is a notable cause of acute diarrhea in young children in Chengdu.
- The study highlights seasonal patterns and the presence of C. jejuni in healthy children, suggesting complex transmission routes.
- Genetic analysis indicated that pediatric C. jejuni infections may stem from diverse but genetically homogeneous strains.
Abstract:
Epidemiological studies on campylobacter jejuni infection in children were carried out in Chengdu during December 1987 to October 1989. Detection rate of campylobacter in 1,092 children with diarrhea was 11.36%, with the highest in children aged 1-2 and the lowest in babies within six months. Campylobacter jejuni could be detected in young children with acute diarrhea all the year round, with a higher detection rate in the spring and summer and lower in the autumn and winter. Campylobacter jejuni could be detected in 5.09% of healthy children, with a significant difference between kindergartens due to their living conditions. Use of spectrum of drug-resistance and plasmid analysis in children of nurseries and kindergartens to study campylobacter infection suggested campylobacter jejuni infection in children could be caused by a lot of distant-associated strains with genetic homogeneity.