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Ranitidine therapy in patients with idiopathic gastric acid hypersecretion. A prospective study
1Department of Medicine, Loma Linda University Medical Center, California, USA.
Digestive Diseases and Sciences
|August 1, 1995
Summary
High doses of ranitidine are effective for idiopathic gastric acid hypersecretion, with some patients needing up to 3000 mg/day. No side effects were observed even with these increased ranitidine dosages.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Idiopathic gastric acid hypersecretion presents a therapeutic challenge.
- Standard ranitidine doses may not be sufficient for all patients.
Purpose of the Study:
- To evaluate the efficacy and dosage requirements of ranitidine in patients with idiopathic gastric acid hypersecretion.
- To assess the safety of higher ranitidine doses in this patient population.
Main Methods:
- Prospective evaluation of 124 patients with idiopathic gastric acid hypersecretion.
- Treatment with ranitidine, with dose adjustments based on therapeutic response.
- Monitoring of basal acid output and ranitidine dosage.
Main Results:
- 56% of patients required increased ranitidine doses (mean 994 mg/day, up to 3000 mg/day).
- A significant correlation was found between basal acid output and required ranitidine dose (r = 0.18, P = 0.05).
- No side effects were reported, even with high ranitidine doses.
Conclusions:
- Ranitidine is an effective treatment for idiopathic gastric acid hypersecretion.
- Higher-than-standard ranitidine doses may be necessary for adequate control.
- High-dose ranitidine therapy is safe and well-tolerated in this condition.