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The linoleic acid metabolite 13-HODE modulates degranulation of human polymorphonuclear leukocytes
M J van de Velde1, F Engels, P A Henricks
1Department of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands.
FEBS Letters
|August 7, 1995
Abstract:
The effect of the linoleic acid metabolite 13-hydroxyoctadecadienoic acid human polymorphonuclear leukocytes (PMNs) was investigated by measuring the expression of CD11b and CD67 on the plasma membrane. 13-HODE (5 microM) by itself induced degranulation of PMNs, but to a lesser extent as compared to PAF and fMLP. In addition, 13-HODE was found to inhibit the PAF-induced degranulation whereas an additive effect on the fMLP-induced PMNs degranulation was observed. These results indicate that 13-HODE can play a modulatory role in degranulation of PMNs.