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PEFR in pregnancy: a longitudinal study

B M Puranik1, G A Kurhade, S B Kaore

  • 1Department of Physiology, Government Medical College, Nagpur.

Indian Journal of Physiology and Pharmacology
|April 1, 1995
PubMed
Summary
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Peak expiratory flow rates (PEFR) in pregnant women decline during gestation and increase postpartum. Anemia is associated with lower PEFR, but the declining trend remains consistent.

Area of Science:

  • Pulmonary Medicine
  • Obstetrics and Gynecology

Background:

  • Peak expiratory flow rate (PEFR) is a measure of pulmonary function.
  • Changes in respiratory mechanics occur during pregnancy.
  • Limited data exists on PEFR trends throughout pregnancy in Indian populations.

Purpose of the Study:

  • To assess monthly changes in PEFR during pregnancy and postpartum.
  • To investigate the correlation of PEFR with gestational age and weight gain.
  • To compare PEFR in anemic versus non-anemic pregnant women.

Main Methods:

  • Prospective study measuring PEFR monthly in 60 pregnant women using Wright's Peak Flow Meter.
  • Data collected from the 3rd month of gestation through postpartum (8-10 weeks).
  • Statistical analysis included regression and correlation with weight and other pulmonary function tests (FVC, FEV1).

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Main Results:

  • PEFR significantly declined from 329.12 lpm in the 3rd month to 286.22 lpm in the 9th month of gestation.
  • Postpartum PEFR increased to 347.86 lpm.
  • PEFR showed a regression rate of 6.68 lpm/month of gestation and 5.49 lpm/kg weight gain.
  • No significant correlation was found between PEFR and FVC or FEV1.
  • Anemic pregnant women had lower PEFR but a similar declining trend.

Conclusions:

  • PEFR decreases progressively during pregnancy in Indian women, with recovery postpartum.
  • Gestational age and weight gain are significant factors influencing PEFR decline.
  • Anemia may exacerbate the reduction in PEFR during pregnancy.