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A new neuronal cell protecting substance, lavanduquinocin, produced by Streptomyces viridochromogenes
K Shin-Ya1, S Shimizu, T Kunigami
1Institute of Cellular and Molecular Biosciences, University of Tokyo, Japan.
The Journal of Antibiotics
|July 1, 1995
Abstract:
A new neuronal cell protecting substance, lavanduquinocin was isolated from Streptomyces viridochromogenes 2942-SVS3. It consists of a carbazole skeleton with an ortho quinone function and a cyclolavandulyl moiety. Lavanduquinocin protected neuronal hybridoma N18-RE-105 cells from L-glutamate toxicity with EC50 value 15.5 nm.