Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Implicit memory in Alzheimer's disease

C Randolph1, M C Tierney, T N Chase

  • 1Department of Psychiatry, Northwestern University Medical School, Chicago, IL 60611, USA.

Journal of Clinical and Experimental Neuropsychology
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sensitivity of the Preclinical Alzheimer's Cognitive Composite (PACC), PACC5, and Repeatable Battery for Neuropsychological Status (RBANS) to Amyloid Status in Preclinical Alzheimer's Disease -Atabecestat Phase 2b/3 EARLY Clinical Trial.

The journal of prevention of Alzheimer's disease·2022
Same author

Cognitive effects of adjuvant endocrine therapy in older women treated for early-stage breast cancer: a 1-year longitudinal study.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2019
Same author

Reply to K. Altundag.

Breast cancer research and treatment·2018
Same author

Cognitive sequelae of endocrine therapy in women treated for breast cancer: a meta-analysis.

Breast cancer research and treatment·2017
Same author

Registries and Cohorts to Accelerate Early Phase Alzheimer's Trials. A Report from the E.U./U.S. Clinical Trials in Alzheimer's Disease Task Force.

The journal of prevention of Alzheimer's disease·2017
Same author

Changes in cerebral glucose metabolism with normal aging.

European journal of neurology·2013
Same journal

The role of disadvantaged childhood conditions on cognitive function and disability in late life: findings from a Swedish longitudinal study.

Journal of clinical and experimental neuropsychology·2026
Same journal

Assessment of facial emotion recognition accuracy and reaction time in patients with social anxiety disorder diagnosed with performance-only specifier.

Journal of clinical and experimental neuropsychology·2026
Same journal

Stability and accuracy of specific learning disability diagnoses from childhood to young adulthood.

Journal of clinical and experimental neuropsychology·2026
Same journal

Performance validity test failure rates among neuropsychological outpatients clinically referred for persistent Long COVID cognitive symptoms following mild SARS-CoV-2 disease severity.

Journal of clinical and experimental neuropsychology·2026
Same journal

Correction.

Journal of clinical and experimental neuropsychology·2026
Same journal

A 50-year personal odyssey through the story of learning disabilities: from primary school to adult LD diagnoses.

Journal of clinical and experimental neuropsychology·2026
See all related articles

Alzheimer's disease patients show normal implicit memory when explicit memory is matched to controls. This suggests explicit memory impairment, not implicit memory deficits, underlies Alzheimer's disease performance on word-stem completion tasks.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • Patients with Huntington's disease (HD) and Korsakoff's syndrome (KS) exhibit preserved implicit memory on word-stem completion tasks.
  • Alzheimer's disease (AD) patients typically show impairments on these implicit memory tasks.
  • Degenerative changes in posterior cortical areas are hypothesized to cause AD deficits, while sparing in KS and HD preserves performance.

Purpose of the Study:

  • To investigate implicit memory performance in Alzheimer's disease (AD) patients.
  • To equate explicit memory performance between AD patients and normal controls.
  • To determine if implicit memory deficits are inherent in AD or secondary to explicit memory impairment.

Main Methods:

  • Utilized a word-stem completion task to assess implicit memory.

Related Experiment Videos

  • Manipulated the number of encoding exposures to equate explicit memory performance.
  • Compared implicit memory performance between AD patients and age-matched controls.

    • Main Results:

    • After equating explicit memory performance, AD patients demonstrated implicit memory performance equivalent to controls.
    • The study found no inherent deficit in implicit memory in AD when explicit memory was controlled.
    • Results challenge the hypothesis that posterior cortical damage directly causes implicit memory impairment in AD.

    Conclusions:

    • The findings suggest that explicit memory deficits, rather than implicit memory impairments, contribute to the observed difficulties in Alzheimer's disease patients on implicit memory tasks.
    • The results support the idea that explicit memory performance level influences implicit memory task outcomes.
    • The study contributes to the understanding of separable neural systems for implicit and explicit memory.