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Related Experiment Videos

Postneonatal screening for congenital syphilis

S Jonna1, M Collins, M Abedin

  • 1District of Columbia General Hospital, Washington, DC, USA.

The Journal of Family Practice
|September 1, 1995
PubMed
Summary

Congenital syphilis is resurging, and current screening may miss cases. Infants born to high-risk mothers might need re-screening at 4-8 weeks due to delayed seroconversion.

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Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Congenital syphilis incidence is rising to epidemic levels.
  • Current screening protocols for congenital syphilis may be insufficient.
  • Maternal risk factors include poor prenatal care and illicit drug use.

Purpose of the Study:

  • To highlight the limitations of current congenital syphilis screening.
  • To advocate for revised screening policies for infants at high risk.

Main Methods:

  • Case series describing three infants with congenital syphilis.
  • Review of maternal risk factors and serological testing at birth and 2 months.

Main Results:

  • All infants and mothers were initially seronegative at birth.

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  • Infants became seropositive for syphilis by 2 months of age.
  • Maternal risk factors were present in all cases.

    • Conclusions:

    • Current screening may fail to detect congenital syphilis promptly.
    • Re-screening infants of high-risk mothers at 4-8 weeks is recommended.
    • Policy review for congenital syphilis screening is warranted.