Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Measuring quantitative serum human chorionic gonadotropin. Variations in levels between kits

C B Smikle1, K A Sorem, F H Wians

  • 1Departments of Obstetric and Gynecology, Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, Texas 78236-5300, USA.

The Journal of Reproductive Medicine
|June 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"Doing something" about the cesarean delivery rate.

American journal of obstetrics and gynecology·2018
Same author

What we still do not know about adrenal vein sampling for primary aldosteronism.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2010
Same author

Assessment of HER-2/neu status in breast cancer. Automated Cellular Imaging System (ACIS)-assisted quantitation of immunohistochemical assay achieves high accuracy in comparison with fluorescence in situ hybridization assay as the standard.

American journal of clinical pathology·2001
Same author

Decreased amniotic fluid index in low-risk pregnancy.

The Journal of reproductive medicine·2001
Same author

Cardiac disease and pregnancy.

Obstetrics and gynecology clinics of North America·2001
Same author

Teaching the Laufe-Piper forceps technique at cesarean delivery.

The Journal of reproductive medicine·2001

Human chorionic gonadotropin (hCG) is vital for monitoring early pregnancy and detecting certain cancers. Understanding the different hCG calibration standards is crucial for accurate clinical interpretation and avoiding diagnostic confusion.

Area of Science:

  • Clinical Chemistry
  • Reproductive Endocrinology
  • Oncology

Background:

  • Human chorionic gonadotropin (hCG) is a key hormone in early pregnancy.
  • hCG serves as a tumor marker for gestational trophoblastic disease, choriocarcinoma, and testicular carcinoma.
  • hCG is also used in antepartum screening for Down syndrome when combined with other markers.

Purpose of the Study:

  • To highlight the clinical applications of human chorionic gonadotropin (hCG) testing.
  • To address potential confusion arising from different hCG calibration standards used in quantitative assays.
  • To advise healthcare practitioners on interpreting hCG results based on laboratory calibration.

Main Methods:

  • Review of the established uses of hCG in clinical practice.

Related Experiment Videos

  • Explanation of the historical and current international standards for hCG calibration (Second International Standard, First International Reference Preparation/Third International Standard).
  • Discussion of the implications of using different standards in quantitative hCG assays.

    • Main Results:

    • Quantitative hCG assays rely on calibration standards established by the World Health Organization.
    • The First International Reference Preparation (IRP) is now recognized as the Third International Standard, and these terms are interchangeable.
    • Discrepancies in quantitative hCG levels can occur when comparing results from laboratories using different calibration standards.

    Conclusions:

    • Awareness of the specific calibration standard used in a laboratory is essential for accurate hCG interpretation.
    • Practitioners must be cognizant of the calibration standard to avoid misinterpretation of quantitative hCG levels.
    • Standardization and clear communication regarding hCG calibration are critical for reliable clinical decision-making.