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Related Experiment Videos

Adrenal incidentaloma, a five year experience

M Terzolo1, G Osella, A Alì

  • 1Department of Clinical and Biological Sciences, University of Turin S. Luigi Hospital, Italy.

Minerva Endocrinologica
|March 1, 1995
PubMed
Summary

Adrenal incidentalomas frequently show silent cortisol hypersecretion, indicated by low DHEA-S and defective dexamethasone suppression. This suggests subclinical hormonal imbalance, though overt Cushing

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Area of Science:

  • Endocrinology
  • Oncology

Background:

  • Adrenal incidentalomas are common, often discovered incidentally during imaging for other conditions.
  • Their endocrine activity is not always apparent, necessitating thorough evaluation.

Purpose of the Study:

  • To investigate the endocrine activity of incidentally discovered adrenal masses.
  • To identify hormonal alterations associated with adrenal incidentalomas.

Main Methods:

  • Studied 45 patients with adrenal incidentalomas.
  • Performed endocrine work-up including urinary catecholamines, plasma renin activity, aldosterone, and hypothalamic-pituitary-adrenal (HPA) axis evaluation (dexamethasone-suppression, o-CRH stimulation).

Main Results:

  • 42% of patients had reduced dehydroepiandrosterone sulfate (DHEA-S) levels.

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  • 14% showed blunted cortisol rhythm, and 15% had defective dexamethasone suppressibility.
  • Silent cortisol hypersecretion was frequently observed, potentially inhibiting the HPA axis.

    • Conclusions:

    • Adrenal incidentalomas are often associated with subclinical hypercortisolism.
    • DHEA-S levels and dexamethasone suppression tests are sensitive markers for detecting silent hypercortisolism.
    • Progression to overt Cushing's syndrome appears unlikely in the short term.