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Rearranged NFKB-2 genes in lymphoid neoplasms code for constitutively active nuclear transactivators

C C Chang1, J Zhang, L Lombardi

  • 1Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.

Molecular and Cellular Biology
|September 1, 1995
PubMed
Summary

Chromosomal rearrangements in the NFKB-2 gene create abnormal proteins that are constitutively active. These altered NF-kappa B transcription factors may drive lymphomagenesis by constantly activating target genes.

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