Circulating hormone levels in a case of granulosa cell tumor

Hormone studies in a case of granulosa cell ovarian tumor were accomplished preoperatively by measuring the plasma steroids and the gonadotropin response to synthetic lutenizing hormone-releasing hormone. Plasma estradiol and estrone were elevated, but not to levels observed preovulation. The base line follicle-stimulating hormone level was markedly supressed and did not respond to luteinizing hormone-releasing hormone, whereas base line and peak luteinizing hormone values were nearly within the normal range. The clinical finding of copious cervical mucus suggested the diagnosis and prompted preoperative documentation of circulating hormone values.