Related Experiment Videos
Substituted thiazolidinediones and thio-imidazolidinones: synthesis, structural study and pharmacological activity
J F Albuquerque1, A Albuquerque, C C Azevedo
1Departamento de Antibiotics, Universidade Federal de Pernambuco, Recife, Brésil.
Die Pharmazie
|June 1, 1995
Abstract:
Synthesis and physico-chemical properties of six 3-(4-bromophenacyl)-5-arylidene-thiazolidine-2,4-diones and eight 3-(4-chlorobenzyl)-5-arylidene-4-thio-imidazolidine-2-ones are described. These products were synthesized by an aldolisation-crotonisation reaction from aromatic aldehydes and 3-substituted thiazolidine-2,4-diones or 4-thio-imidazolidine-2-ones. Hypoglycemic and peripheral antinociceptive activities were investigated for these compounds.