Related Experiment Videos
Mismatch negativity to auditory stimulus change recorded directly from the human temporal cortex
J D Kropotov1, R Näätnen, A V Sevostianov
1Laboratory for Neurobiology of Action Programming, Institute of the Human Brain of Russian Academy of Sciences, St. Petersburg.
Psychophysiology
|July 1, 1995
Summary
Mismatch negativity (MMN), an auditory event-related potential, is generated by auditory change detection. Intracranial recordings revealed MMN originates in a specific temporal cortex area, independent of attention.
Area of Science:
- Neuroscience
- Auditory Perception
- Event-Related Potentials
Background:
- Mismatch negativity (MMN) is an attention-independent event-related potential (ERP) reflecting auditory change detection.
- MMN is thought to arise from comparing deviant auditory input with a neural memory trace of repetitive stimuli.
- Previous research localized MMN generation to broader cortical regions.
Purpose of the Study:
- To precisely localize the intracranial generation of MMN in the human temporal cortex.
- To investigate the relationship between MMN and attention-dependent responses (N2, P3) to auditory changes.
Main Methods:
- Recorded intracranial electroencephalography (EEG) from electrodes implanted in the temporal cortex of patients.
- Presented auditory frequency change stimuli to elicit MMN, N2, and P3 responses.
- Analyzed MMN generation sites and compared them with locations of attention-dependent ERPs.
Main Results:
- Intracranially recorded MMN was confirmed to be attention-independent.
- MMN generation was localized to a small, specific area within the temporal cortex.
- Attention-dependent N2 and P3 responses were recorded in different cortical structures.
Conclusions:
- MMN generation is confined to a distinct, localized region in the human temporal cortex.
- This specific area is distinct from the neural substrates of attention-dependent auditory processing.
- Intracranial recordings provide high-resolution localization of MMN generators.