Electrophysiology of intestinal cholecystokinin secretion
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Updated: Oct 9, 2026

Whole Cell Electrophysiology of Primary Cultured Murine Enterochromaffin Cells
Published on: September 26, 2018
1Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Abstract:
The control of gastrointestinal CCK secretion may occur at several points. A decrease in potassium conductance may depolarize the plasma membrane, activating calcium channels with a resultant stimulation in CCK release. The opposite may occur with increases in potassium conductance. The model presented in Fig. 8 suggests that the key control point in the understanding of CCK secretion is the regulation of L-type calcium channels. Whether a single second messenger pathway may regulate calcium channels stimulated by agents such as glucose, phenylalanine, bombesin and cAMP is an important area to pursue.
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