Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Norplant: systemic immunological complications--case report

A Campbell1, N Brautbar

  • 1Center for Immune, Environmental, and Toxic Disorders and University of Texas Health Science Center, Houston.

Toxicology and Industrial Health
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurements of the [Formula: see text][Formula: see text] production cross sections in the [Formula: see text] channel in proton-proton collisions at [Formula: see text] and [Formula: see text] and combined constraints on triple gauge couplings.

The European physical journal. C, Particles and fields·2015
Same author

Eccentric Fatigue Modulates Stretch-shortening Cycle Effectiveness--A Possible Role in Lower Limb Overuse Injuries.

International journal of sports medicine·2015
Same author

Discarded Human Thymus Is a Novel Source of Stable and Long-Lived Therapeutic Regulatory T Cells.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

Constraints on the pMSSM, AMSB model and on other models from the search for long-lived charged particles in proton-proton collisions at [Formula: see text].

The European physical journal. C, Particles and fields·2015
Same author

Distributions of topological observables in inclusive three- and four-jet events in pp collisions at [Formula: see text][Formula: see text].

The European physical journal. C, Particles and fields·2015
Same author

Evidence for Collective Multiparticle Correlations in p-Pb Collisions.

Physical review letters·2015
Same journal

The history of the Toxicology Roundtable-75 years of scientific discussion.

Toxicology and industrial health·2026
Same journal

Perfluorooctane sulfonate (PFOS) increases metastatic potential of thyroid cancer cells in correlation with activation of multiple invasion-related signaling proteins.

Toxicology and industrial health·2026
Same journal

Biological and computational evidence of dinotefuran-DNA interactions: A combined <i>in</i> <i>vitro</i> and <i>in</i> <i>silico</i> study.

Toxicology and industrial health·2026
Same journal

Dibromoacetonitrile mediated depression-like behavior in mice and induced HT22 cytotoxicity through the MKP-1/P38 MAPK signaling pathway and the antagonistic effect of N-acetylcysteine.

Toxicology and industrial health·2026
Same journal

Subchronic γ-hexachlorocyclohexane exposure is associated with altered TLR4-linked pulmonary immune responses following endotoxin challenge: Insights from a two-hit mouse model.

Toxicology and industrial health·2026
Same journal

Humanin improved the rotenone-induced reactive oxygen species formation in PC12 cells by modulating the SIRT3/Nrf2/HO-1 signaling pathway.

Toxicology and industrial health·2026
See all related articles

This case report details a patient experiencing systemic complications from the Norplant system, involving both hormonal and immunological reactions to the Silastic implants. It highlights a rare instance of failed Norplant device leading to adverse health effects.

Area of Science:

  • Reproductive Medicine
  • Immunology
  • Pharmacology

Background:

  • The Norplant system utilizes subdermal implants containing levonorgestrel for long-term contraception.
  • Levonorgestrel is a synthetic progestin commonly found in contraceptives, delivered via diffusion through Silastic capsules.
  • The system is designed to suppress ovulation and thicken cervical mucus, inhibiting conception.

Observation:

  • A patient presented with systemic complications linked to the Norplant system.
  • These complications stemmed from both the endocrinological effects of levonorgestrel and immunological responses to the Silastic implants.
  • The patient's Norplant device was identified as having failed.

Findings:

  • The case describes a rare instance of systemic immunological complications associated with a Norplant device.

Related Experiment Videos

  • This represents the first reported case in Western medical literature of such immunological issues arising from a failed Norplant system.
  • The complications involved a combination of hormonal and immunological adverse effects.

    • Implications:

    • This case underscores the potential for rare but serious systemic complications from contraceptive implants.
    • It highlights the importance of considering immunological reactions to implant materials, not just hormonal effects.
    • Further investigation into the long-term safety and potential adverse reactions of subdermal contraceptive devices is warranted.