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Bovine glomerular amyloidosis: morphological studies

K Nordstoga1, Z Y Zhou, G Husby

  • 1Department of Morphology, Genetics and Aquatic Biology, Norwegian College of Veterinary Medicine, Oslo.

Zentralblatt Fur Veterinarmedizin. Reihe A
|December 1, 1994
PubMed
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Bovine kidney amyloid deposits contain more cellular remnants than in other species, potentially explaining unique tissue properties and histone content in these amyloid proteins.

Area of Science:

  • Veterinary pathology
  • Immunohistochemistry
  • Electron microscopy

Background:

  • Bovine kidney amyloidosis is characterized by glomerular deposits.
  • Amyloid composition can vary between species, affecting its properties.

Purpose of the Study:

  • To investigate the composition of amyloid deposits in bovine kidneys.
  • To compare bovine amyloid with that found in other animal species.

Main Methods:

  • Immunohistochemistry using rabbit anti-horse AA serum and avidin biotin complex.
  • Transmission electron microscopy to examine amyloid fibril and cellular remnant content.

Main Results:

  • Bovine glomerular amyloid masses showed a significant admixture of cellular remnants.

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  • These cellular remnants were more abundant than in amyloid from other animal species.
  • Amyloid deposits obscured cellular structures in severely affected glomeruli.

    • Conclusions:

    • The high content of cellular remnants may influence the tinctorial properties of bovine amyloid.
    • This finding could explain the relatively high histone content observed in bovine amyloid proteins.