The effect of endo- and exogenous melanin on Zn2+ and Co2+ elimination and distribution in mice

The content of endogenous melanin in white Balb c and black C-57 Bl. mice affected Zn2+ and Co2+ accumulation, elimination and distribution following intraperitoneal administration of these ions. Elimination of Co2+ ions was significantly greater in white mice than in black mice. Accumulation of Zn2+ was higher than that of Co2+ and did not depend on melanin content in mice. The same response was observed upon administration of exogenous melanin. Both ions accumulated mainly in spleen and heart irrespective of melanin content.