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Multiple sclerosis in Scandinavia and Finland

N Koch-Henriksen¹

¹Danish Multiple Sclerosis Registry, Rigshospitalet, Copenhagen.

Acta Neurologica Scandinavica. Supplementum

|January 1, 1995

Summary

Multiple Sclerosis (MS) incidence rates in Scandinavia and Finland show inconsistent temporal fluctuations. Notably, the typical north-south risk gradient for MS was not observed in the northernmost regions of Norway.

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Area of Science:

Neurology
Epidemiology
Environmental Health

Background:

Multiple Sclerosis (MS) is a chronic neurological disease with a known geographical distribution.
Previous research suggests a north-south gradient in MS risk, particularly in Europe.
Understanding temporal trends in MS incidence is crucial for public health planning.

Purpose of the Study:

To analyze long-term incidence trends of Multiple Sclerosis (MS) across diverse Scandinavian and Finnish regions.
To investigate temporal fluctuations in MS incidence rates over several decades.
To evaluate the consistency of the established north-south MS risk gradient at high latitudes.

Main Methods:

Systematic review and meta-analysis of epidemiological studies on MS incidence.
Inclusion of data from seven geographically distinct areas in Scandinavia and Finland.
Analysis of incidence rates spanning several decades to identify temporal patterns.

Main Results:

Significant temporal fluctuations in MS incidence were observed in most studied areas.
The pattern of these fluctuations was inconsistent across the geographical regions.
The lowest MS incidence was recorded in the northernmost parts of Norway, challenging the traditional north-south gradient.

Conclusions:

MS incidence in Scandinavia and Finland exhibits complex and inconsistent temporal dynamics.
The widely accepted north-south gradient for MS risk may not apply universally, especially at high Arctic latitudes.
Further research is needed to elucidate the etiological factors influencing MS epidemiology in these regions.

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