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Pancuronium does not decrease oxygen consumption during hypothermic or normothermic cardiopulmonary bypass

V Werlhof1, D I Sessler

  • 1NT Enloe Hospital, Chico, California, USA.

Anesthesia and Analgesia
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

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Muscle relaxation did not significantly reduce oxygen consumption during cardiopulmonary bypass, even during hypothermia. This study found no significant decrease in systemic oxygen use with pancuronium in either normothermic or hypothermic bypass patients.

Area of Science:

  • Anesthesiology
  • Cardiovascular Surgery
  • Physiology

Background:

  • Hypothermic cardiopulmonary bypass can reduce systemic oxygen consumption.
  • A proposed mechanism involves mitigating hypothermia-induced muscle tone (microshivering).
  • Pancuronium is a neuromuscular blocking agent used for muscle relaxation.

Purpose of the Study:

  • To test if pancuronium administration decreases systemic oxygen consumption during hypothermic cardiopulmonary bypass.
  • To determine if this effect differs between hypothermic and normothermic bypass conditions.

Main Methods:

  • Studied patients undergoing normothermic (37.6°C) and hypothermic (28.2°C) cardiopulmonary bypass.
  • Measured systemic oxygen consumption using the Fick principle before and after pancuronium administration (0.15 mg/kg).

Related Experiment Videos

  • Compared oxygen consumption changes between the two temperature groups.

    • Main Results:

    • Oxygen consumption averaged 93 mL.min⁻¹m⁻² in normothermic and 43 mL.min⁻¹m⁻² in hypothermic groups.
    • Pancuronium decreased oxygen consumption by only 2% in normothermic patients.
    • Pancuronium also decreased oxygen consumption by only 2% in hypothermic patients, failing to confirm the hypothesis.

    Conclusions:

    • Muscle relaxation with pancuronium did not significantly reduce systemic oxygen consumption in either normothermic or hypothermic cardiopulmonary bypass.
    • The hypothesis that pancuronium inhibits hypothermia-induced microshivering to reduce oxygen demand was not supported by these findings.