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Intravenous regional anesthesia with meperidine

I Acalovschi1, T Cristea

  • 1University of Medicine and Pharmacy, Department of Anaesthesia and Intensive Care, Clinical Hospital, Cluj-Napoca, Romania.

Anesthesia and Analgesia
|September 1, 1995
PubMed
Summary
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Meperidine demonstrated local anesthetic properties in intravenous regional anesthesia (IVRA), with faster onset but slower recovery than lidocaine. Its use for IVRA is a secondary option due to increased side effects compared to lidocaine.

Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Intravenous regional anesthesia (IVRA) is a technique for limb surgery.
  • Assessing alternative agents for IVRA is crucial for patient safety and efficacy.

Purpose of the Study:

  • To evaluate the efficacy and safety of meperidine as a local anesthetic in IVRA.
  • To compare meperidine with lidocaine and saline for IVRA of the upper limb.

Main Methods:

  • A double-blind, randomized study involving 45 volunteers divided into three groups.
  • Groups received IVRA with meperidine, lidocaine, or sodium chloride.
  • Onset and recovery of sensory and motor blocks were assessed, along with adverse effects.

Main Results:

  • Meperidine showed a faster onset of sensory block than saline but slower than lidocaine.

Related Experiment Videos

  • Complete motor block was achieved in all meperidine and lidocaine groups, but less so in the saline group.
  • Meperidine group experienced higher incidence of dizziness, nausea, and injection site pain.

    • Conclusions:

    • Meperidine exhibits local anesthetic effects on peripheral nerves in vivo.
    • Meperidine is a potential alternative for IVRA, particularly for patients with local anesthetic allergies.
    • Lidocaine remains a preferred agent due to a better side effect profile.