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Cytokines in Sjögren's syndrome
F N Skopouli1, H M Moutsopoulos
1Dept of Internal Medicine, Medical School, University of Ioannina, Greece.
Annales De Medecine Interne
|January 1, 1995
Abstract:
This review discusses the respective role in Sjögren's syndrome of pro-inflammatory cytokines, such as interleukin (IL)-1 beta and tumour-necrosis factor-alpha, and anti-inflammatory cytokines, such as transforming growth factor-beta, interferon-alpha and IL-10. The former products are secreted by lymphocytes as well as epithelial cells. Th 1 cell cytokines predominate within the focal infiltrates. Increased levels of circulating IL2 receptors correlate to the progression of the ongoing disease.