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Sjögren's syndrome and virus

X Mariette1

  • 1Service d'Immuno-Hématologie, Hôpital Saint-Louis, Paris.

Annales De Medecine Interne
|January 1, 1995
PubMed
Summary

This review examines the conflicting evidence regarding viral roles in Sjögren

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Area of Science:

  • Virology
  • Immunology
  • Autoimmune Diseases

Background:

  • Sjögren's syndrome (SS) is an autoimmune disorder primarily affecting exocrine glands.
  • The potential role of viral infections in SS pathogenesis remains a subject of ongoing research and debate.

Purpose of the Study:

  • To review and discuss the conflicting findings concerning viral involvement in Sjögren's syndrome.
  • To evaluate the evidence for specific viruses implicated in the pathogenesis of SS.

Main Methods:

  • Review of existing literature on viral detection in Sjögren's syndrome.
  • Analysis of studies using techniques like in situ hybridization and polymerase chain reaction.
  • Evaluation of serological data and its limitations.

Main Results:

  • Epstein-Barr virus (EBV) has been detected in labial salivary glands (LSG) of SS patients.
  • Hepatitis C virus (HCV) has been suspected, but serological results may be confounded by false positives.
  • Evidence suggests potential involvement of retroviruses, including human T lymphotropic virus type 1 (HTLV-1), in LSG.

Conclusions:

  • The exact viral etiology of Sjögren's syndrome is not definitively established.
  • Conflicting data necessitates further rigorous investigation into the role of viruses like EBV, HCV, and retroviruses.
  • Understanding viral contributions is crucial for developing effective therapeutic strategies for SS.

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