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Role of ADF/TRX and its inhibitor on the release of major basic protein from human eosinophils
H Koyanagi1, N Wakasugi, K Yoshimatsu
1Department of Pediatrics and Medical Biology & Parasitology, Jichi Medical School, Tochigi, Japan.
Biochemical and Biophysical Research Communications
|August 24, 1995
Abstract:
Adult T cell leukemia-derived factor (ADF)/Thioredoxin (TRX), originally defined as an IL-2 receptor alpha-chain/p55 inducer, has many cytokine-like activities. We reported that the release of major basic protein (MBP) from mature eosinophils stimulated with cytochalasin B and C5a were augmented after preincubation with recombinant ADF/TRX. The addition of a TRX specific inhibitor, BE40644, suppressed the augmentation of MBP release from mature eosinophils. It is suggested that BE40644 is applicable in allergic diseases associated with eosinophils.