Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ventral pallidum self-stimulation: a moveable electrode mapping study

G Panagis1, E Miliaressis, Y Anagnostakis

  • 1Department of Basic Sciences, School of Medicine, University of Crete, Heraklion, Greece.

Behavioural Brain Research
|June 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Music exposure attenuates anxiety- and depression-like behaviors and increases hippocampal spine density in male rats.

Behavioural brain research·2019
Same author

Regulation of brain reward by the endocannabinoid system: a critical review of behavioral studies in animals.

Current pharmaceutical design·2013
Same author

Stimulation of the medial forebrain bundle: behavioral dissociation of its rewarding and activating effects.

Neuroscience letters·2009
Same author

GABA antagonists reverse the somatostatin dependent attenuation of rat locomotor activity.

Neuropeptides·2009
Same author

Effects of delta9-tetrahydrocannabinol on reward and anxiety in rats exposed to chronic unpredictable stress.

Journal of psychopharmacology (Oxford, England)·2009
Same author

Activation of somatostatin receptors in the globus pallidus increases rat locomotor activity and dopamine release in the striatum.

Psychopharmacology·2008

Electrical self-stimulation (ESS) is prevalent in the ventral pallidum (VP) of rats, indicating its significant role in reward pathways. Findings suggest the VP is a heterogeneous reward structure with varying functional properties.

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Reward System Research

Background:

  • The ventral pallidum (VP) is implicated in reward processing, but its precise role and functional organization remain incompletely understood.
  • Electrical self-stimulation (ESS) is a valuable tool for mapping reward circuitry in the brain.
  • Previous studies have identified reward-related functions in various brain regions, but the VP's specific contribution requires detailed investigation.

Purpose of the Study:

  • To systematically map the distribution of electrical self-stimulation (ESS) foci within the rat ventral pallidum (VP).
  • To characterize the relationship between ESS parameters (rate-frequency functions) and electrode location within the VP and adjacent areas.
  • To determine the VP's contribution to reward circuitry by comparing its ESS properties to known reward areas.

Related Experiment Videos

Main Methods:

  • Utilized moveable electrodes to map ESS in rats, recording bar-pressing rates across varying electrical stimulation frequencies.
  • Collected ESS data from multiple sites within the VP and neighboring nuclei (globus pallidus, caudate).
  • Applied a sigmoid model to rate-frequency functions to derive key parameters: asymptotic rate and threshold frequency.

Main Results:

  • ESS was detected at 98% of VP sites and 66% of adjacent sites, with significant variability in maximum rates (14-85 presses/min) and threshold frequencies (10.2-36.4 pulses/train).
  • Extra-pallidal areas showed fewer low-frequency threshold sites compared to the VP.
  • The lowest ESS thresholds in the VP were slightly higher than those in established reward centers, suggesting the VP is a key reward structure.
  • Threshold frequencies decreased along the rostrocaudal axis of the VP, indicating functional heterogeneity.

Conclusions:

  • The ventral pallidum is a critical and widespread substrate for reward processing in the brain.
  • The VP exhibits functional heterogeneity regarding reward, with distinct properties along its rostrocaudal axis.
  • These findings support the VP's integral role in the brain's reward circuitry and provide a detailed map of its self-stimulation properties.