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Related Experiment Videos

The high risk heart donor: potential pitfalls

D A Bull1, R D Stahl, D L McMahan

  • 1Division of Cardiothoracic Surgery, University of Utah School of Medicine, Salt Lake City 84132, USA.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|May 1, 1995
PubMed
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Bacterial transmission from donor hearts to recipients can occur, particularly with gram-negative bacteria, leading to serious infections and potentially death. Gram-positive bacteria in donor hearts did not cause infectious complications in recipients.

Area of Science:

  • Transplantation immunology
  • Infectious disease transmission
  • Bacteriology

Background:

  • Donor heart scarcity necessitates exploring all available sources for transplantation.
  • The risk of bacterial transmission from infected donors to recipients is a critical concern.

Observation:

  • Nineteen of 360 heart donors had positive blood cultures pre-harvest.
  • Gram-positive bacteremia (Staphylococcus, Streptococcus) was observed in 16 donors.
  • Gram-negative bacteremia (Serratia, Acinetobacter, E. coli) occurred in 3 donors.

Findings:

  • Two of three recipients receiving hearts from gram-negative bacteremic donors developed severe infections (endocarditis, mediastinitis, sepsis).
  • Identical organisms and sensitivities confirmed donor-to-recipient transmission in these cases.

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  • No infectious complications occurred in recipients of hearts from 16 donors with gram-positive bacteremia.

    • Implications:

    • Bacterial transmission from donor hearts is a documented risk in transplantation.
    • Gram-negative bacterial transmission poses a significant threat of morbidity and mortality to heart transplant recipients.
    • Careful donor screening and management are crucial to mitigate infection risks in heart transplantation.