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Evaluation of a new preservation solution: Celsior in the isolated rat lung. Paris-Sud University Lung Transplatation
J Reignier1, M Mazmanian, A Chapelier
1Laboratoire de Chirurgie Expérimentale, Centre chirurgical Marie Lannelongue, Plessis-Robinson, France.
Background:
We compared Celsior solution, a new and original extracellular preservation solution, with blood-based Wallwork's solution.
Methods:
In two groups of isolated rat lungs submitted to 4 hours of cold ischemia, pulmonary arterial and venous resistances, coefficient of filtration, and wet-to-dry lung weight ratio were determined at baseline and after 90 minutes of reperfusion.
Results:
After ischemia-reperfusion, percentage of increases above the respective baseline coefficient of filtration values were 93% +/- 7% in the Wallwork group and 7% +/- 3% in the Celsior group (p < 0.001 versus Wallwork's solution).
Conclusions:
These results show that Celsior consistently prevented the ischemia-reperfusion-induced increase in pulmonary microvascular permeability as compared with Wallwork's solution.