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Chemotherapy for gliomas

S M Chang¹, M D Prados

¹University of California, San Francisco, USA.

Current Opinion in Oncology

|May 1, 1995

Summary

This summary is machine-generated.

Malignant gliomas have a poor prognosis despite advances in treatment. This review covers current chemotherapy and chemoradiation protocols for adult gliomas, highlighting nitrosoureas as active agents.

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Area of Science:

Neuro-oncology
Medical oncology
Brain tumor research

Background:

Malignant gliomas have a poor prognosis despite surgical and radiation therapy advances.
Few chemotherapeutic agents are specifically developed for brain tumors.
Nitrosoureas are among the most active antitumor agents for gliomas.

Purpose of the Study:

To review current chemotherapeutic and chemoradiation protocols for adult gliomas.
To highlight the role of nitrosoureas in glioma treatment.

Main Methods:

Literature review of existing chemotherapeutic and chemoradiation protocols.
Analysis of treatment strategies for primary and recurrent gliomas.

Main Results:

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Chemotherapy and chemoradiation remain key treatment modalities for gliomas.

Nitrosourea-based regimens show significant antitumor activity.

Conclusions:

Despite challenges, current protocols offer treatment options for adult gliomas.
Continued research into novel agents and combination therapies is crucial.