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Ki-1 anaplastic primary cutaneous large-cell lymphoma

C Stenier1, A Bourlond, Y Humblet

  • 1Service de Dermatologie, Cliniques universitaires Saint-Luc, Bruxelles, Belgique.

Dermatology (Basel, Switzerland)
|January 1, 1995
PubMed
Summary

Localized cutaneous anaplastic large-cell lymphoma (ALCL) in a 63-year-old woman presented as a subumbilical nodule. This high-grade lymphoma showed a favorable prognosis, with surgery or radiotherapy being effective treatments.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Anaplastic large-cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma.
  • Cutaneous localization of ALCL can present unique diagnostic and prognostic challenges.

Observation:

  • A 63-year-old female patient presented with a significant, ulcerated nodule in the subumbilical region.
  • The nodule was histopathologically identified as Ki-1-positive anaplastic large-cell lymphoma.

Findings:

  • The lymphoma exhibited exclusive localization to the skin (cutaneous anaplastic large-cell lymphoma).
  • Despite being high-grade, this specific case demonstrated a less severe clinical course and prognosis.
  • Surgical excision and local radiotherapy were identified as potentially curative or sufficient treatment modalities.

Implications:

  • Localized cutaneous ALCL may have a more favorable prognosis than systemic forms.
  • This case supports the efficacy of localized treatment approaches for skin-limited ALCL.
  • Further research into the specific characteristics and management of cutaneous ALCL is warranted.

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