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Related Experiment Videos

Characterization of biomedical polymer surface interaction with human factor Xa

G Lewis1, J Newman, W Katz

  • 1Department of Mechanical Engineering, University of Memphis, TN 38152, USA.

Bio-Medical Materials and Engineering
|January 1, 1995
PubMed
Summary

Surface analysis of biomedical polymers revealed consistent protein adsorption patterns. These findings aid in selecting materials for cardiovascular devices.

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Surface Chemistry

Background:

  • Biomedical polymers are crucial for cardiovascular devices.
  • Understanding polymer-surface interactions with biological molecules is essential for device safety and efficacy.
  • Factor Xa adsorption influences thrombogenicity and biocompatibility.

Purpose of the Study:

  • To characterize the surface and near-surface layers of biomedical polymers after exposure to Factor Xa.
  • To evaluate the consistency of results from different surface analytical techniques.
  • To discuss the clinical significance for cardiovascular component material selection.

Main Methods:

  • Utilized angular-dependent X-ray photoelectron spectroscopy (ADXPS).
  • Employed static secondary ion mass spectrometry (SSIMS).

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  • Analyzed low-density polyethylene, expanded polytetrafluoroethylene, and silicone elastomer exposed to Factor Xa in buffer.

    • Main Results:

    • Spectroscopic measurements provided consistent data on surface and near-surface composition.
    • Characterized the adsorption of Factor Xa on the tested biomedical polymers.
    • Demonstrated the reliability of combining ADXPS and SSIMS for surface analysis.

    Conclusions:

    • The study confirms the utility of ADXPS and SSIMS in characterizing protein-polymer interactions.
    • Results support the use of these techniques for screening biomedical polymers for cardiovascular applications.
    • Consistent findings enhance confidence in material selection for blood-contacting devices.