Immunochemical detection of metallothionein in brain

Polyclonal and monoclonal antibodies have been used to determine the levels of metallothionein (MT) isoforms in the brain, its regions, and its cellular elements. MT is found abundantly in the astrocytes but not in the oligodendroglia or microglia. The induction of astrocytic metallothionein by cytokines suggests an important role for this protein in providing long-term protection against oxidative damage in tissue injury and inflammation.