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Columbin isolated from calumbae radix affects the sleeping time of anesthetized mice
1Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan.
Biological & Pharmaceutical Bulletin
|April 1, 1995
Abstract:
In a screening series of bioactive components in edible and medicinal plants, we found that Calumbae Radix (Colombo root, 1% powdered feed, for 5 d) and its component, columbin (20-40 mg/kg/d, for 5 d, orally), shortened the sleeping time induced by a urethane and alpha-chloralose mixture and prolonged the sleeping time induced by hexobarbital in mice.