Anti-remodeling effects of ACE inhibitors

Extensive experimental and clinical work has demonstrated the prognostic importance of ventricular remodeling following myocardial infarction. Indeed these structural changes may represent one of the more important prognostic determinants of outcome in this setting. Significant advances have been made in the pharmacologic attenuation of remodeling specifically through the use of ACE inhibitor therapy. Ongoing and future studies should provide clinical information on the mechanisms initiating the remodeling process and thereby allow the development of even more effective therapeutic strategies to attenuate this process.