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Related Experiment Videos

Surface modification of albumin microspheres

Z B Shafi1, G P Martin, C J Olliff

  • 1Department of Pharmacy, University of Brighton, Moulescoomb, E. Sussex.

Journal of Drug Targeting
|January 1, 1995
PubMed
Summary

Researchers developed albumin microspheres (MS) with varying surface properties. They found that linking ligands like spermine to hydrophilic MS alters their surface tension, indicating potential for tailored drug delivery applications.

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Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Nanotechnology

Background:

  • Albumin microspheres (MS) are versatile biomaterials with applications in drug delivery.
  • Controlling the surface properties of MS, such as hydrophobicity, is crucial for optimizing their performance.
  • Chemical crosslinking offers a method to modify MS surfaces.

Purpose of the Study:

  • To prepare submicron-sized hydrophobic and hydrophilic albumin microspheres (MS).
  • To investigate the effect of surface modification, specifically spermine linkage, on MS hydrophobicity.
  • To evaluate the feasibility of using water-soluble carbodiimide for ligand conjugation to MS.

Main Methods:

  • Preparation of hydrophobic and hydrophilic albumin microspheres (MS) via chemical crosslinking.

Related Experiment Videos

  • Surface modification of hydrophilic MS by linking spermine.
  • Quantification of hydrophobicity using a novel sedimentation volume technique.
  • Measurement of surface tension (ST) for all MS types.

    • Main Results:

    • Hydrophobic MS exhibited a surface tension of 31 mN m-1.
    • Hydrophilic MS had a surface tension of 68 mN m-1.
    • Spermine-linked MS displayed heterogeneous hydrophilic characteristics with surface tensions ranging from 62 to 71 mN m-1.
    • Successful ligand conjugation to MS was achieved using water-soluble carbodiimide.

    Conclusions:

    • Albumin microspheres with tunable surface properties (hydrophobic, hydrophilic, and heterogeneous) can be prepared.
    • Spermine linkage significantly alters the surface characteristics of hydrophilic MS, creating heterogeneous surfaces.
    • Water-soluble carbodiimide is an effective reagent for linking ligands to albumin microspheres.