Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

REM sleep in primary depression: a computerized analysis

R J McPartland, D J Kupfer, P Coble

    Electroencephalography and Clinical Neurophysiology
    |April 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Therapeutic drug monitoring of mood stabilizers in Medicaid patients with bipolar disorder.

    The American journal of psychiatry·1999
    Same author

    Relationship between social rhythms and mood in patients with rapid cycling bipolar disorder.

    Psychiatry research·1999
    Same author

    Diagnostic certainty of a voluntary bipolar disorder case registry.

    Journal of affective disorders·1999
    Same author

    Cerebral glucose metabolic response to combined total sleep deprivation and antidepressant treatment in geriatric depression.

    The American journal of psychiatry·1999
    Same author

    Insulin-like growth factor 1 and growth hormone binding protein in depression: a preliminary communication.

    Journal of psychiatric research·1999
    Same author

    Consensus criteria for traumatic grief. A preliminary empirical test.

    The British journal of psychiatry : the journal of mental science·1999
    Same journal

    Coming to terms with brain waves.

    Electroencephalography and clinical neurophysiology·2014
    Same journal

    Habituation of lower leg stretch responses in Parkinson's disease.

    Electroencephalography and clinical neurophysiology·2000
    Same journal

    Asymmetry of cortical excitability revealed by transcranial stimulation in a patient with focal motor epilepsy and cortical myoclonus.

    Electroencephalography and clinical neurophysiology·2000
    Same journal

    Evoked isometric muscle contractions in myopathies: analysis of pathophysiological properties by different stimulus patterns.

    Electroencephalography and clinical neurophysiology·2000
    Same journal

    Task-related coherence and task-related spectral power changes during sequential finger movements.

    Electroencephalography and clinical neurophysiology·2000
    Same journal

    Electrophysiological studies in mild idiopathic carpal tunnel syndrome.

    Electroencephalography and clinical neurophysiology·2000
    See all related articles

    This study analyzed rapid eye movement (REM) sleep in depression patients, finding REM frequency was high initially, unlike in healthy individuals. This suggests an early-night REM pressure in depression.

    Area of Science:

    • Neuroscience
    • Sleep Medicine
    • Psychiatry

    Background:

    • Primary depression is associated with altered sleep patterns.
    • Rapid eye movement (REM) sleep, a crucial stage for cognitive function, is often disrupted in depressive disorders.

    Purpose of the Study:

    • To automatically analyze REM sleep parameters in inpatients with primary depression.
    • To investigate the temporal dynamics of REM sleep across consecutive nights.
    • To compare REM sleep patterns in depressed patients with those of healthy subjects.

    Main Methods:

    • Automated analysis of 7 consecutive nights of REM sleep in 35 primary depression inpatients during placebo administration.
    • Calculation of REMs number, voltage integral, duration sum, and average REM size.

    Related Experiment Videos

  • Validation of automated measures against manual scoring and investigation of REM sleep changes throughout the night.

    • Main Results:

    • Automated REM measures demonstrated validity through significant correlations with manual scoring.
    • REM time remained constant across REM periods, similar to normal subjects.
    • Average REM size increased significantly from REM period 2-3 and 3-4.
    • REM frequency was elevated in the first REM period, decreased significantly by the second, and then stabilized, differing from normal sleep patterns.
    • A significant inverse correlation was found between first REM period frequency and REM latency.

    Conclusions:

    • Depressed patients exhibit a unique REM sleep pattern characterized by high initial REM frequency.
    • This pattern suggests an increased pressure for REM sleep at the beginning of the night in depression.
    • The findings indicate potential neurobiological differences in REM sleep regulation in primary depression.