Localization of proteinase expression in the developing rabbit brain
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1INSERM U134, Hôpital de la Salpêtrière, Paris, France.
Brain Research. Developmental Brain Research
|May 26, 1995
Abstract:
In developing rabbit brain we studied expression of metalloproteinases (MMP) 1 and 3 by in situ hybridization and MMP2 and tissue and urokinase-type plasminogen activators (tPA and uPA) by immunohistochemistry. All are detected in developing cell populations. Mature olfactory bulb neurons express MMP1 and MMP3. uPA is expressed by glial cells during myelination and by mature cortical neurons. MMP2 is expressed by mature subpial and perivascular astrocytes.