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[Serotoninergic receptors and cardiovascular diseases]
1Sección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, San Pedro de Macoris, República Dominicana.
Gaceta Medica De Mexico
|May 1, 1994
Summary
Serotonin (5-hydroxytryptamine or 5-HT) influences cardiovascular function, affecting blood pressure via 5-HT1A and 5-HT2 receptors. Targeting these receptors may help manage hypertension and thromboembolism.
Area of Science:
- Cardiovascular Pharmacology
- Neuropharmacology
Context:
- Serotonin (5-hydroxytryptamine, 5-HT) is a biogenic amine with significant roles in cardiovascular physiology and pathology.
- 5-HT's dual action on blood pressure involves lowering it via central 5-HT1A receptors and raising it through vascular smooth muscle 5-HT2 receptor stimulation.
Purpose:
- To explore the role of serotonin (5-HT) in cardiovascular regulation, specifically in arterial hypertension and thromboembolism.
- To investigate the potential of modulating 5-HT receptors for therapeutic interventions.
Summary:
- Hypofunction of 5-HT1A receptors or overstimulation of 5-HT2 receptors may contribute to arterial hypertension.
- Agonists of 5-HT1A receptors (e.g., indorenate) and antagonists of 5-HT2 receptors (e.g., ketanserin) show potential in controlling hypertension.
- Ketanserin and pelanserin demonstrated efficacy in attenuating hemodynamic changes in experimental thromboembolism, indicating 5-HT's involvement.
- 5-HT may also be linked to angor pectoris in hypertension and atherosclerosis, potentially due to endothelial dysfunction promoting vasoconstriction.
Impact:
- This research highlights serotonin receptor modulation as a potential therapeutic strategy for managing hypertension and related cardiovascular conditions.
- Understanding 5-HT's role in thromboembolism and endothelial dysfunction could lead to novel treatment approaches.