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Mucosal mantle cell (centrocytic) lymphomas

M Fraga1, E Lloret, L Sanchez-Verde

  • 1Department of Pathology, Hospital Clinico, Santiago de Compostela, Spain.

Histopathology
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

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Mantle cell lymphoma (MCL) primarily in the mucosa behaves aggressively, similar to nodal MCL, and disseminates widely. Distinguishing it from mucosa-associated lymphoid tissue (MALT) lymphomas is crucial, with CD5 reactivity being a key differentiator.

Area of Science:

  • Oncology
  • Hematology
  • Pathology

Background:

  • Mantle cell lymphoma (MCL), also known as centrocytic lymphoma, is a distinct subtype of non-Hodgkin lymphoma.
  • Mucosa-associated lymphoid tissue (MALT) lymphomas typically arise in extranodal sites and have a generally indolent clinical course.

Observation:

  • This study reviewed four cases of MCL presenting primarily in mucosal sites (gastric, large bowel, tonsil).
  • Tumors exhibited a monomorphic pattern of mantle cells (centrocytes) with diffuse or vaguely nodular arrangement.
  • Epithelial infiltration was observed in two cases, and CD5 expression was consistently positive.

Findings:

  • All four MCL cases demonstrated a CD19, CD20, CD5, IgD, Leu8 immunophenotype, with absent KiM1P and CD10 expression.
  • PRAD-1/Cyclin D1 overexpression was detected in three cases, suggesting a genetic basis.

Related Experiment Videos

  • The MCL cases showed disseminated disease involving lymph nodes, spleen, or bone marrow.

    • Implications:

    • Mucosal MCL exhibits aggressive behavior and a tendency for dissemination, contrasting with the localized nature of MALT lymphomas.
    • CD5 reactivity is a valuable marker for differentiating mucosal MCL from MALT lymphomas.
    • Accurate distinction is essential for appropriate clinical management and prognosis.